NUR 2063 Essentials of Pathophysiology

Pathophysiology Module 1 – 3 Exam Review

What are mediators of inflammation?

- histamine, bradykinins, complement, clotting factors, cytokines, chemokines

events in inflammation

- increased vascular permeability and fluid shift, emigration of leukocytes, phagocytosis

rapid hypersensitivity reaction

- allergies, anaphylaxis, sneezing. Mediated by igE antibodies

type 2 cytotoxic hypersensitivity

- autoimmune destruction as a result of IgG or IgM binding with antigen. hemolytic

disease of a new born or if someone gets a blood transfusion from someone of a

different blood type

Type 3 hypersensitivity reaction

- immune complex, example is autoimmune disease like lupus or rheumatoid arthritis

Type 4 hypersensitivity reaction, Delayed reaction

- T-cell mediated disorders like TB test