CHOLESTEROLHYPERLIPIDEMIA
CLINICAL PRACTICE GUIDELINE ASSIGNMENT
HELEN GAMADA
NR511: DIFFERENTIAL DIAGNOSIS
DR. MARGARET SMITH
AUGUST 2019
INCIDENCE AND PREVALENCE IN U.S.
In 2015-2016- > 12% of adults had total cholesterol >240 mg/dL
18% had HDL level < 40 mg/dL
95 million U.S. adults age > 20 had total cholesterol level > 200
mg/dL
Nearly 1 in 3 Americans have high cholesterol
29 million total cholesterol levels > 240 mg/dL
7% adolescents age 6-19 had high total cholesterol
("High Cholesterol Facts, " 2019)
PATHOPHYSIOLOGY
Cholesterol types
Low-Density Lipoprotein (LDL)
Very Low-Density Lipoprotein
High-Density Lipoprotein (HDL)
Is an essential lipophilic molecule for human life
has many roles for the normal function of cells
Is an essential component of the cell membrane
Is a precursor molecule in vitamin D synthesis, steroid hormones,
sex hormones
Is a constituent of bile salt-used in the digestion of fat-soluble
vitamins A,D, E, and K
("Hypercholesterolemia (high blood cholesterol) information | myVMC," n.d.).
PATHOPHYSIOLOGY CONT…
High cholesterol -major risk factor for
the formation of atherosclerotic plaques
Endothelial damage leads to
dysfunction of endothelial cells
Atherosclerotic plaque begins to
develop in damaged inner lining
More cholesterol and other materials
accumulate
Plaque continues to grow and block
blood flow plaque ruptures a blood
clot forms blockage
("Hypercholesterolemia (high blood cholesterol) information |
myVMC," n.d.).
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Language | English |
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