BIOS 390 – Molecular Biology Week 2 Quiz Study Guide BIOS 390 – Molecular Biology Week 2 Quiz Study Guide

BIOS 390 – Molecular Biology

Week 2 Quiz Study Guide

Question Set 1

(TCO 3) DNA replication is said to be semiconservative because

Each daughter DNA molecule consists of one strand from the parent DNA

molecule and one new strand.

 (TCO 3) DNA synthesis occurs in

The 5' to 3' direction.

 (TCO 3) Which of the following statements is correct?

The growth and development or healing of wound in an organism require

new cells. The new cells in organism come from division of preexisting cells.

DNA is the material in body which has all structural and functional

information for body. Therefore each cell needs a full instruction in the form

of DNA to work properly. So before cell division the DNA need to be replicate

into two and transfer to new cell as a source of information.

The DNA replication occur before cell division in S-phase of cell cycle. The

DNA replication occur in nucleus of eukaryotic cell while prokaryotic cells do

not have nucleus and their cell division occur in cytoplasm.

Question Set 2

 (TCO 3) During DNA replication, DNA ligase is most active on the lagging

strand.

This is because

The lagging strands contain more short DNA segments than the leading

strand, and these short segments are ligated together with DNA ligase

 (TCO 3) Phosphodiester bonds are formed between adjacent Okazaki

fragments by

DNA ligase. DNA polymerase is the enzyme that carries in the daughter

nucleotides, and DNA helicase is the one that unwinds the double helix to

open the replication fork.

 (TCO 3) Which of the following activities are unique for DNA polymerase I?

DNA polymerase I has 2 enzymatic function.

1. Polymerase activity

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 5' to 3' DNA dependent and RNA dependent polymerization.

2. Exonuclease activity

5' to 3' exonuclease during nick translation

3' to 5' exonuclease in proof reading.

Question Set 3

 (TCO 3) Once bound to an origin of replication, the origin replication

complex (ORC) recruits

The first proteins to bind the DNA are said to “recruit” the other proteins.

Two copies of an enzyme called helicase are among the proteins recruited to

the origin. Each helicase unwinds and separates the DNA helix into singlestranded DNA. As the DNA opens up, Y-shaped structures called replication

forks are formed.

 (TCO 3) Positive supercoils ahead of the replication fork are resolved by

DNA gyrase.

Question Set 4

 (TCO 3) Replication licensing ensures that

Control of DNA replication licensing in a cell cycle. To maintain genome

integrity in eukaryotes, DNA must be duplicated precisely once before cell

division occurs. A process called replication licensing ensures that

chromosomes are replicated only once per cell cycle.

 (TCO 3) Pre-replication complex assembly

(TCO 3) Find the incorrect statement. (Describe the replication processes.)

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